The history of Ufam begins in January 17, 1909, with the foundation of "Escola Universitária Livre de Manaus" integrated by Sciences and Letter School, Law and Social Sciences School, Medicine, Pharmacy, Dentistry and Midwife course.
At October 22, 1913, the Escola changed its name to Universidade de Manaus, remaining so until 1926. With the fall of economic rubber cycle, the city got empty and the population experienced a long time period of uncertainty and needs. So in 1926 the Universidade stopped its activities, remaining some isolated unities. Only the Law course remained, maintained by Federal Government from 1949.
At June 12, 1962, was created the "Fundação Universidade do Amazonas", through the Federal Law of number 4069-A, of authorship of Senator Arthur Virgílio Filho. However, it was only at January 17, 1965, the installation was opened, in memory of former "Escola Universitária Livre de Manaus". For 37 years the University remained with the initials “UA”.
With the Law number 10.468, of June 20, 2002, the institution received the nomenclature of Universidade Federal do Amazonas, using from this moment the initials “Ufam”.